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3PKSTUDIES*2CLINICAL STUDIES(JOINT & DOMS)20STUDY META-ANALYSIS& SYSTEMATIC REVIEWApplication versatilityWater dispersibility offers versatilityin applications such as powderedbeverages, stick packs, capsules, tablets, gummies & chews, shots& RTDsTurmXTRA™60N is a proprietary water-dispersible turmeric extract standardized to 60% curcuminoids content (with all 3 active curcuminoids). We have validated it through multiple preclinical, human pharmacokinetic trials to establish bioequivalence of -World's best 250mgcurcuminoids for every format≈1 TurmXTRA™60N250mg | Single DoseStd. 95% turmeric extract1575mg | 3 dosesAward winning support forjoint and muscle health Higher consumer complianceA low dose once a day provides higher consumer compliance Application easeTurmXTRA™60N allows you to put afull dose of turmeric into the capsule while leaving space for more ingredients, giving you flexibility to combine turmeric with other synergistic ingredientsAll-naturalNo use of synthetic excipients and surfactants allowing your end product to obtain a clean labelA complete clinical packageAny of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose, treat cure, or prevent any disease.TurmXTRA™ mark is a registered trademark of Nutriventia Limited.*Including our latest one comparing TurmXTRA with a branded 95% turmeric extract with piperine
A complete clinical packagePHARMACOKINETIC STUDY250mg of TurmXTRA™60N is clinically substantiated to show equivalence to 1575mg of standard 95% turmeric extract. Our 2 separate Human PK studies drew the same set of results which guaranteed consistent quality of TurmXTRA™60N.*Clinical Pharmacology: Advances & Application, Dove Medical PressChange in time in80-meter fast-paced walkMore agility~2x improvementJoint comfortimprovement19%Mobilityimprovement2xJOINT HEALTH STUDYOur randomized, double-blind placebo-controlled study on 96 healthy volunteers showed the efficacy of TurmXTRA™60N on joint health with significant results.Time (s)Change in pain (VAS) after80-meter fast-paced walkMore comfort~3x improvementVASChange in time in9-stair climbMore agility~1.5x improvementTime (s)Average concentration (ng/ml)Effective concentrationTime (hrs)Human PK Study 1 Human PK Study 2*Time (hrs)Average concentration (ng/ml)Effective concentrationTurmXTRA™60N Reference ProductTurmXTRA™60N PlaceboSource: Thanawala S, Shah R, Alluri KV, Somepalli V, Vaze S, Upadhyay V. Comparative bioavailability of curcuminoids from a water-dispersiblehigh curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over, comparative, pharmacokinetic study. J PharmPharmacol. 2021 Apr 27;73(6):816-823. doi: 10.1093/jpp/rgab028. PMID: 33755149.Journal of Pharmacy and Pharmacology, Oxford University PressAny of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose, treat cure, or prevent any disease.TurmXTRA™ mark is a registered trademark of Nutriventia Limited.
A complete clinical packageDELAYED ONSET MUSCLE SORENESS (DOMS) STUDYOur randomized, double-blind, placebo-controlled trial on 30 healthy and recreationally active subjects showed the efficacy of TurmXTRA™60N in reducingmuscle soreness and increasing psychological well-being.TurmXTRA™60N PlaceboSource: Thanawala S, Shah R, Karlapudi V, Desomayanandam P, Bhuvanendran A. Efficacy and Safety of TurmXTRA® 60N in Delayed Onset MuscleSoreness in Healthy, Recreationally Active Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial. Evid Based Complement AlternatMed. 2022 Aug 5;2022:9110414. doi: 10.1155/2022/9110414. PMID: 35966736; PMCID: PMC9374544.Change in Recovery Timecompared to placeboChange in Muscle Soreness Recovery as compared to placeboHigher recovery96 hrs post-workout1.5x improvementMean Sleep Quality ScoreTime (hr)Change in Sleep (H&M Scale)compared to placeboPercentage RecoveryFaster recoveryIn H&M - Fatigue Scale~4x improvementBetter Sleep48 hrs post-workout1.3x improvementChange in pain & discomfort (VAS)compared to placeboMore comfort48 hrs post-workout~6x improvementVASChange in LDH levelscompared to placeboBetter Recovery72 hrs post-workout~9x improvementMean LDH levelsAny of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose, treat cure, or prevent any disease.TurmXTRA™ mark is a registered trademark of Nutriventia Limited
HEALTH BENEFITSJointhealthSkinhealthBrainhealthImmunehealthLiverhealthnutriventia.com | info@nutriventia.comDistributed in the USA by Aviva Natural SupplementsDistributed in Europe by Vivatis Pharma GmbHLICENSES & CERTIFICATIONSA complete clinical packageMETA-ANALYSIS: TURMERIC, CURCUMIN ANDMUSCULOSKELETAL HEALTHA systematic review and meta-analysis of 20 randomized clinical trials (RCTs) that evaluated the effective dose, safety, and efficacy of commercial turmeric extract and curcumin supplements in musculoskeletal health found that TurmXTRA™60N at a low dose of 250mg/day was found to be as or more effective than other curcumin products.Included in the analysis were 7 studies on skeletal muscle health and 13on joint health using varying doses and duration of single ingredientturmeric extracts.
Broad spectrum of bioactivesProlanza® has a high concentration (4-5%) of its 10 USP compliant Withanolides.The ingredient also contains 10 additionally identified Withanolides.One-a-day dosageA single small dose of 300mg/day is sufficient due to the long-acting biological action and high bioavailability offered by Prolanza®Clinically substantiated for stress managementProlanza® is clinically proven to provide adaptogenic support for a prolonged period, making it ideal for formulations designed to efficiently manage all-day stressRoot-only, USP & broad spectrum, 1-a-dayashwagandhaAshwagandha, renowned for its adaptogenic properties, is traditionally consumed multipletimes a day.Prolanza® is a unique long-acting ingredient formulated from ashwagandha root extract which boasts of 20 Withanolides among which 10 are USP compliants. Prolanza® innovative release pattern ensures extended clinical benefits withjust one daily dose.Long-acting ashwagandha forall-day stress supportHEALTH BENEFITSSleepHealthStressSupportMentalWellbeingCognitiveSupportPRACTICAL APPLICATIONSCapsulesGummy ready(taste masked)Any of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose, treat, cure or prevent any disease.Prolanza® mark is a registered trademark of Nutriventia Limited.Prolanza® showed 9.5x less stress,12x better bioavailability than a top ashwagandha ingredient.Learn more
*Study Source: International Journal of Basic & Clinical Pharmacology, Medip Academy (2022)*Study Source: Evidence-Based Complementary and Alternative Medicine, Hindawi (2021)PHARMACOKINETIC STUDY*Compared to a leading branded Ashwagandha ingredient, Prolanza® showed -Superior Relative BioavailabilityProlanza® has a bioavailability which is nearly12 times higher as compared to the reference product.Extended AvailabilityProlanza® is available in the body forup to 8-12 hours. A comprehensive clinical packageSTRESS & COGNITIVE HEALTH STUDY*A randomized, double-blind, placebo-controlled 3 month study on 100 healthy subjects with mild to moderate stress demonstrated the efficacyof Prolanza® with statistically significant results -Sleep Health3.5x more improvement in sleep qualityStress Support9.3x more improvement in perceived stress1.7x more decrease in serum cortisol levelsOverall Mental Wellbeing2x improvement in overall mental wellbeing**Cognitive Support3.6x greater improvement in memory recall1.5x greater improvement in visual accuracySource: Alluri VKR, Thanawala S, Upadhyay V. A comparative pharmacokinetics studyof Ashwagandha (Withania somnifera)Root Extract sustained-release capsules: an open-label, randomized, two treatment, two-sequence, two period, single-dosecrossover clinical study. Int J Basic Clin Pharmacol 2022;11:26-34**Change in Oxford Happiness Questionnaire (OHQ) Source: Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and Safety of Ashwagandha Root Extracton Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based ComplementAlternat Med. 2021 Nov 30;2021:8254344. doi: 10.1155/2021/8254344. PMID: 34858513; PMCID: PMC8632422.Average concentration (ng/mL)Time (hr)05 10 15 20 25Prolanza®ReferenceLICENSES & CERTIFICATIONSnutriventia.com | info@nutriventia.comDistributed in the USA by Aviva Natural SupplementsDistributed in Europe by Vivatis Pharma GmbH
nutriventia.com | info@nutriventia.comDistributed in the USA by Aviva Natural SupplementsDistributed in Europe by Vivatis Pharma GmbHLICENSES & CERTIFICATIONSHEALTH BENEFITSSleepregulationAntioxidantsupportCognitivehealthImmunehealthWeightmanagementSUSTAINED RELEASE PROFILEReleases 50% in the first hourSubsequent release per hour in smaller dosesTapering off after 6 hoursTime (hrs)% Release101 2 3 4 5 6 7 892030405060708090Melotime™
Caffeine stimulates the nervous system leadingto improved alertness, exemplified motor coordination, and recharged focus. The most significant issue with caffeine is that its effects start to diminish after a couple of hours dueto quick absorption of caffeine within the body. High and/or multiple doses leads to caffeine tolerance which could lead to jitteriness, headache, and nervousness collectivelyknown as ‘caffeine crash’. CaffXtend™ is a unique patent-pending product that delivers natural caffeine consistently for 12 hours,from a natural matrix using our proprietary modified-release technology.Long-acting caffeine All-naturalSource of natural caffeine is fromcoffee seeds. This caffeine is embedded in a natural release controlling matrixLong-acting, once a day doseA single dose designed for an enhanced caffeine experience, lasting up to 12 hours, offers all-day alertness and focusAny of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose, treat, cure, or prevent any disease.CaffXtend™ mark is a registered trademark of Nutriventia Limited.MARKET INSIGHTS79% of active consumers consume energy supplements to improve energy & stamina and 63% of these consumers prefer natural source of caffeine in their sports nutrition productsSource - NBJCaffXtend releases consistent caffeine, providing 12-hour sustained energy with no caffeine crash Learn more HEALTH BENEFITSPRACTICAL APPLICATIONSHardcapsulesGummy ready(taste masked)ImprovedfocusSports nutrition & gamingZaps you in action with 12-hourfocus & alertness
Time (hrs)% release201385068788487902 4 6 8 10 12 14406080100SUSTAINED RELEASE PROFILEClinically substantiated to provide significantly lower levels of ‘tiredness’ for an extended duration (12 hours) from a single doseClinically substantiated to be safeCaffXtend™ releases the caffeine consistently, giving 12 hours of sustained energy* & focus*The claims of energy are more in terms of the general meaning of the word rather than energy as referred to as ATP productionExtended action through sustainedrelease profile of CaffXtend™ capsules**1.Extended Tmax – 391.57%(to reach maximum concentration)Extended half-life T½ – 22.32% longerSignificantly lower scoresfor ‘tired’ and ‘jittery’3.Lesser perception of tiredness and jittersLower scores for parametersindicative of ‘caffeine crash’4.No caffeine crash, hence saferExtended efficacy through sustainedrelease profile of CaffXtend™ from a Caff-VAS (Caffeine Research Visual Analog Scales)** significantly higher scores for ‘overall mood’, ‘relaxed’and ‘alert’2.Better mood & more alertCaffXtend™ is beneficial with better efficacy, as compared to repeated caffeine dosing5.**Substantiated from data of human clinical trial compared with equal dose of natural caffeinePHARMACOKINETIC STUDYSource: Shefali Thanawala, Rajat Shah, R. Abiraamasundari, R. Senthurselvi & PrabakaranDesomayanandam (2023): Comparative Bioavailability and Benefits on Mental Functions ofNovel Extended-Release Caffeine Capsules against Immediate-Release Caffeine Capsules:An Open-Label, Randomized, Cross-over, Single-Dose Two-Way Crossover Study, Journalof Dietary Supplements, DOI: 10.1080/19390211.2022.2160529CaffXtend™ Reference productMean concentration (ng/mL)Time (hrs)LICENSES & CERTIFICATIONSCaffXtend™nutriventia.com | info@nutriventia.comDistributed in the USA by Aviva Natural SupplementsDistributed in Europe by Vivatis Pharma GmbH
PHARMOKINETIC STUDYClinically substantiated through a randomized double-blind, parallel arm, placebo-controlled clinical trial to evaluate the pharmacokinetic profile of Vitamin C from an extended action tablet of C-Fence™. Clinical trial shows that the 12-hour release profile correspondingly produces a sustained level of Vitamin C in the active state in plasma providing a 24-hour in-vivo coverage of Vitamin C to the body.Mean Concentration (ng/mL)Time (hrs)85xxC-Fence™Placebo20xExtendedTmaxCmax comparedto baseline 0hrs85xC24 compared to baseline 0hrs20xTime (hrs)% Release202 4 6 8 10 12 14406080100IN VITRO DISSOLUTIONSingle oral administration provides a consistent release for maximum timePolymer matrixWorks by diffusion mechanism from the matrixRelease in small burstsHEALTH BENEFITSAntioxidantSkinhealthBrainhealthImmunehealthCardiovascularhealthLICENSES & CERTIFICATIONSJournal of Pharmacology and Pharmacotherapeutics, Sage JournalsC-Fence™nutriventia.com | info@nutriventia.comDistributed in the USA by Aviva Natural SupplementsDistributed in Europe by Vivatis Pharma GmbH
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0 2 4 6 8 10 12 14 16 18 20 22 2400.511.522.53ReferenceAshwanova®Time (hrs.)Mean plasma concentration of totalwithanolidies (ng/mL)Ashwanova®Ashwanova®Ashwanova®Ashwanova®