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3PKSTUDIES3CLINICAL STUDIESJOINT, DOMS, OA1META-ANALYSIS ANDSYSTEMATIC REVIEWApplication versatilityWater dispersibility offers versatilityin applications such as powderedbeverages, stick packs, capsules, tablets, gummies & chews, shots& RTDs-3 human pharmacokinetic trials confirming in-studybio-equivalence of 250mg TurmXTRA™ 60N with 1575mgTurmeric Extract (95% curcuminoids)-2 clinical trials in healthy human subjects have proven theefficacy of TurmXTRA™ 60N in improving joint comfort andproviding with muscle relief-1 clinical trial in subjects with osteoarthritis has establishedclinical efficacy of TurmXTRA™ 60N in improving joint mobilityand comfort while reducing anti-inflammatory markersAward winning ingredient Higher consumer complianceA low dose once a day provides higher consumer compliance. Application easeTurmXTRA™ 60N's ~ 250mg once daily dose provides efficacy and unprecedented flexibility in combining turmeric with complementary ingredients to enhance your formulation.All-naturalNo use of synthetic excipients and surfactants.A complete clinical packageLearn more >World's first Curcuma longaingredient with a completeclinical package at 250mgone-a-day dose.Any of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose, treat cure, or prevent any disease.TurmXTRA™ mark is a registered trademark of Nutriventia Limited.

A complete clinical package3 PHARMACOKINETIC STUDYSTUDY 1 AND STUDY 2 – One 250 mg dose of TurmXTRA™60N is clinically substantiated to show equivalenceto three 500 mg doses of standard 95% turmeric extract. Our 2 separate Human PKstudies drew the same set of results which guaranteed consistent quality ofTurmXTRA™60N.Pharmacokinetic study 1Pharmacokinetic study 3Source: Thanawala S, Shah R, Alluri KV, Somepalli V, Vaze S, Upadhyay V. Comparative bioavailability of curcuminoidsfrom a water-dispersible high curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over,comparative, pharmacokinetic study. J Pharm Pharmacol. 2021 Apr 27;73(6):816-823. doi: 10.1093/jpp/rgab028.PM ID: 33755149.Time (h)Mean plasma concentration of totalcurcuminoids (ng/mL)004 8 121020 24203040506070809016TurmXTRA™60N Std 95%TETurmXTRA™60N Time (h)Mean plasma concentration of totalcurcuminoids (ng/mL)004 8 121020 24203040506016Std 95%TEPharmacokinetic study 2STUDY 3 -One 250 mg dose of TurmXTRA™60N is clinically substantiated to show comparable kinetics to three 500 mg doses of a branded turmeric extract plus piperine taken at three different time intervals. Source: Thanawala S, Shah R, Doyle L, Upadhyay V. Comparative pharmacokinetics of curcuminoids from waterdispersible turmeric extract against a curcuminoids-piperine combination : An open label, randomized, balanced,2-Treatment, 2-Sequence, 2-Period Crossover Study. Alt Ther. 2024 Apr; 30 (4) : 18-23Mean plasma concentration of totalcurcuminoids (ng/mL)005 6 10 12102020304050607015TurmXTRA™60N Branded TE+5mg piperineAny of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose, treat cure, or prevent any disease.TurmXTRA™ mark is a registered trademark of Nutriventia Limited.

TurmXTRA™60N PlaceboSource: Thanawala S, Shah R, Karlapudi V, Desomayanandam P, Bhuvanendran A. Efficacy and Safety of TurmXTRA® 60N in Delayed Onset MuscleSoreness in Healthy, Recreationally Active Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial. Evid Based Complement AlternatMed. 2022 Aug 5;2022:9110414. doi: 10.1155/2022/9110414. PMID: 35966736; PMCID: PMC9374544.STUDY 5 - DELAYED ONSET MUSCLE SORENESS DOMS STUDYOur randomized, double-blind, placebo-controlled trial on 30 healthy and recreationally active subjects showed the efficacy of TurmXTRA™60N in reducingmuscle soreness and increasing psychological well-being.Change in Recovery Timecompared to placeboChange in Muscle Soreness Recovery as compared to placeboHigher levels of recovery96 hrs post-workout1.5x improvementTime (hr)Percentage RecoveryFaster recoveryIn H&M - Fatigue Scale4 times fasterChange in LDH levelscompared to placeboBetter Recovery72 hrs post-workout~9x improvementVASChange in time in80-meter fast-paced walkMore agility~2x improvementJoint comfortimprovement19%Mobilityimprovement2xOur randomized, double-blind placebo-controlled study on 96 healthy volunteers showed the efficacy of TurmXTRA™60N on joint health with significant results.Time (s)Change in pain (VAS) after80-meter fast-paced walkMore comfort~3x improvementVASChange in time in9-stair climbMore agility~1.5x improvementTime (s)TurmXTRA™60N PlaceboSource: Thanawala S, Shah R, Alluri KV, Somepalli V, Vaze S, Upadhyay V. Comparative bioavailability of curcuminoids from a water-dispersiblehigh curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over, comparative, pharmacokinetic study. J PharmPharmacol. 2021 Apr 27;73(6):816-823. doi: 10.1093/jpp/rgab028. PMID: 33755149.Journal of Pharmacy and Pharmacology, Oxford University PressSTUDY 4 - JOINT HEALTH STUDYAny of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose, treat cure, or prevent any disease.TurmXTRA™ mark is a registered trademark of Nutriventia Limited

2.4 times improvementVisual analog scale (100 mm)HEALTH BENEFITSJointhealthSkinhealthBrainhealthImmunehealthLiverhealthnutriventia.com | info@nutriventia.comLICENSES & CERTIFICATIONSScan to visit websitefor more informationOur randomized, double-blind, placebo controlled, parallel group 90-day study on 139 subjects with mild to moderate knee osteoarthritis proved the efficacy and safety of TurmXTRA™60N in significantly reducing pain and improving comfort & knee function.STUDY 6 - OSTEOARTHRITIS STUDYManuscript under publicationReduced Pain (KOOS) Better Knee FunctionNearly 4x times improvement 2.3 times improvementTurmXTRA™60N PlaceboChange in pain (VAS) ascompared to placeboBetter Comfort (VAS)Knee Injury and Osteoarthritis Outcome scoreChange in pain (KOOS)as compared to placeboChange in knee related quality oflife as compared to placeboKOOS – Pain scoreVAS – Pain scoreEase in knee mobility

USP compliantMultiple randomized, double-blind, placebo controlled clinicaltrials validating one-a-day dose for managing stress.Validated with a full clinical package for prolongedrelease and one a day dose.TMAlso known as ashwanova™ProlanzaTM is a unique long-acting ingredientof ashwagandha root extract which compliesto 10 USP Withanolides. It’s innovative releasepattern ensures extended clinical benefits.PHARMACOKINETIC STUDY*Compared to a leading branded Ashwagandha ingredient, ProlanzaTM showed -Superior Relative BioavailabilityProlanzaTM has a bioavailability which is nearly12 times higher as compared to the reference product.Extended AvailabilityWithanolides from ProlanzaTM are available in plasma for upto24 hours A comprehensive clinical package0 2 4 6 8 10 12 14 16 18 20 22 2400.511.522.53ReferenceTime (hrs.)Mean plasma concentration of totalwithanolidies (ng/mL)Learn more >Root-only, USP compliant,1-a-day ashwagandha

***Manuscript under publicationSTUDY 2 – A STRESS & COGNITIVE HEALTH STUDYA randomized, double-blind, placebo-controlled 3 month study on 100 healthy subjects with mild to moderate stress demonstrated the efficacy of ProlanzaTM with statistically significant results as compared to placebo. *STUDY 3 – MULTI ARM - STRESS STUDYRandomized, double-blind, placebo-controlled, 60 days, multi arm study on126 mild to moderate stressed.Improvement in subjects taking ProlanzaTM as comparedto Placebo after 60 days

Mimics 8-hour naturalsleep patternMelatonin will capture 58% ($820M) of thehealth sleep market, driven by 65% ofconsumers seeking supplements for sleepmanagement, a prevalent driver of sales.Source - NBJMARKET INSIGHTSLearn more >Melotime™ is a patent-pending and proprietary extended-release melatonin ingredient that helps mimic the body’s natural sleep pattern and supports quality sleep. The unique release profileof Melotime™ ensures a release of a significant portion in the first hour followed by continuous release of melatonin upto 6 hours for maintenance. This ensures a quick on-set and maintains good quality of sleep.Timed release, melatonin Any of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose,treat, cure or prevent any disease.Melotime™ is a trademark of Nutriventia Limited.Melotime showed upto 50% release in1st hour, with periodic release in a6-hour interval for uninterrupted sleepStick packs(powder)8-hour sustained sleepSustained release profile helps to get 8 hours of sleep without side effectsSupports natural sleep patternThe unique release profile provides a quick onset and good quality restorative sleep.PRACTICAL APPLICATIONSTabletsCapsulesGummies & chews

LICENSES & CERTIFICATIONSScan to visit websitefor more informationDistributed in the USA by Aviva Natural SupplementsDistributed in Europe by Vivatis Pharma GmbHnutriventia.com | info@nutriventia.comHEALTH BENEFITSSleepregulationAntioxidantsupportCognitivehealthImmunehealthWeightmanagementSUSTAINED RELEASE PROFILEReleases upto 50% in the first hourSubsequent release per hour in smaller burstsExtended action through sustained release profile of Melotime™Extended half-life (T1/2) –5.1 h for Melotime vs 1.01 h for Melatonin IRPHARMACOKINETIC STUDYMelotime Melatonin IRTime (h)0180001600014000120001000080006000400020000Mean plasma concentration ofmelatonin (pg/mL)1 2 3 4 5 6 7 8Disturbed sleepSound sleepFastereliminationSlowerelimination

Caffeine stimulates the nervous system leading to improved alertness, exemplified motor coordination, and recharged focus. The most significant issue with caffeine is that its effects start to diminish after a couple of hours dueto quick absorption of caffeine within the body. High and/or multiple doses leads to caffeine tolerance which could lead to jitteriness, headache, and nervousness collectivelyknown as ‘caffeine crash’. CaffXtend™ is a unique patent product that delivers natural caffeine for 12 hours, from a natural matrix using our proprietary modified-release technology.Long-acting caffeine 79% of active consumers consume energysupplements to improve energy & stamina and63% of these consumers prefer natural sourceof caffeine in their sports nutrition products.Source - NBJMARKET INSIGHTSHEALTH BENEFITSSports nutrition& gamingImprovedfocusPRACTICAL APPLICATIONSHardcapsulesStick packs(powder)All-naturalSource of natural caffeine is fromcoffee seeds. This caffeine is embedded in a natural release controlling matrixLong-acting, once a day doseA single dose designed for an enhanced caffeine experience, lasting up to 12 hours, offers all-day alertness and focusAny of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose, treat, cure, or prevent any disease.CaffXtend™ mark is a registered trademark of Nutriventia Limited.CaffXtend™ provides 400% lesserperception of fatigue in comparison toregular natural caffeineLearn more >12 hour Boost forfocus & alertness

SUSTAINED RELEASE PROFILEClinically substantiated to reduce perception of ‘tiredness’ for an extended duration (12 hours) from a single doseCaffXtend™'s sustained release of Caffeine gives 12 hours of enhanced energy* and focus*The claims of energy are more in terms of the general meaningof the word rather than energy as referred to as ATP productionExtended action through sustainedrelease profile of CaffXtend™1.Extended Tmax – 391.57%(to reach maximum concentration)Extended half-life T½ – 22.32% longerSignificantly lower scoresfor ‘tired’ and ‘jittery’3.Lesser perception of tiredness and jittersLower scores for parametersindicative of ‘caffeine crash’4.No caffeine crash, hence saferExtended efficacy through sustainedrelease profile of CaffXtend™ from a Caff-VAS (Caffeine Research Visual Analog Scales)** significantly higher scores for ‘overall mood’, ‘relaxed’and ‘alert’2.Better mood & more alertnessCaffXtend™ is beneficial with better efficacy, as compared to repeated caffeine dosing5.Substantiated from data of human clinical trialcompared with equal dose of natural caffeinePHARMACOKINETIC STUDY#Source: Shefali Thanawala, Rajat Shah, R. Abiraamasundari, R. Senthurselvi & PrabakaranDesomayanandam (2023): Comparative Bioavailability and Benefits on Mental Functions ofNovel Extended-Release Caffeine Capsules against Immediate-Release Caffeine Capsules:An Open-Label, Randomized, Cross-over, Single-Dose Two-Way Crossover Study, Journalof Dietary Supplements, DOI: 10.1080/19390211.2022.2160529LICENSES & CERTIFICATIONSnutriventia.com | info@nutriventia.comScan to visit websitefor more informationSharp declineImmediate spikeProgressiveincreaseGradualdeclineMean concentration (pg/ml)0 2 4 6 8 10 120500100015002000250030003500400045005000Time (hrs.) Caffeine IR

C-Fence™ is a direct compressible granularsystem of Vitamin C which is an ideal solutionfor manufacturers targeting convenient andcontinuous 24-hour antioxidant shield. Poweredusing our modified release technology, smallbursts of Vitamin C are consistently releasedperiodically, providing 24 hr antioxidant support.Unlike other sustained release products that aretime-consuming to develop and manufacture,C-Fence™ just needs a single-step operation tocompress granules into tablets.24-hour optimised Vitamin Cdirect compressible granulesLong-acting, once a day doseA single dose provides 24-hour protection making it convenient for end consumers.Natural flowVitamin C is inherently hygroscopic,and poor flow properties. However, C-Fence™ crafted using nature-derivedexcipients and patented proprietaryprocess, offers seamless flow, enhancingmanufacturing convenience.Assured consistencyEach batch of C-Fence™ undergoes pre-quality evaluation by testingtablets from a representative sample.Saftey with low doseC-Fence™ averts gastric distension bygradually releasing controlled Vitamin Cbursts.60% of consumers incorporate Vitamin C intotheir daily routine to bolster their immune system.Source - NBJMARKET INSIGHTSHEALTH BENEFITSTabletsAny of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose,treat, cure, or prevent any disease.C-Fence™ mark is a registered trademark of Nutriventia Limited.Learn more >Shields you for 24 hourVitamin C protectionC-fence™ has shown 12-hr sustainedrelease Vitamin C in-vitro.C-Fence™ is a direct compressible granularsystem of Vitamin C which is an ideal solutionfor manufacturers targeting convenient andcontinuous 24-hour antioxidant shield. Poweredusing our modified release technology, smallbursts of Vitamin C are consistently releasedperiodically, providing 24 hr antioxidant support.Unlike other sustained release products that aretime-consuming to develop and manufacture,C-Fence™ just needs a single-step operation tocompress granules into tablets.24-hour optimised Vitamin Cdirect compressible granulesLong-acting, once a day doseA single dose provides 24-hour protection making it convenient for end consumers.Natural flowVitamin C is inherently hygroscopic,and poor flow properties. However, C-Fence™ crafted using nature-derivedexcipients and patented proprietaryprocess, offers seamless flow, enhancingmanufacturing convenience.Assured consistencyEach batch of C-Fence™ undergoes pre-quality evaluation by testingtablets from a representative sample.Saftey with low doseC-Fence™ averts gastric distension bygradually releasing controlled Vitamin Cbursts.60% of consumers incorporate Vitamin C intotheir daily routine to bolster their immune system.Source - NBJMARKET INSIGHTSHEALTH BENEFITSTabletsAny of these statements have not been evaluated by the Food and Drug Administration. This ingredient is not intended to diagnose,treat, cure, or prevent any disease.C-Fence™ mark is a registered trademark of Nutriventia Limited.Learn more >Shields you for 24 hourVitamin C protectionC-fence™ has shown 12-hr sustainedrelease Vitamin C in-vitro.

PHARMOKINETIC Clinically substantiated through a randomized double-blind, parallel arm, placebo-controlled clinical trial to evaluate the pharmacokinetic profile of Vitamin C from an extended action tablet from C-Fence™. Clinical trial shows that the 12-hour release profile correspondingly produces a sustainedlevel of Vitamin C in the active state in plasma providing a 24-hour in-vivo coverage.IN VITRO DISSOLUTIONSingle dose provides a consistent release for maximum timePolymer matrixWorks by diffusion mechanism from the matrixRelease in small burstsHEALTH BENEFITSAntioxidantSkinhealthBrainhealthImmunehealthCardiovascularhealthLICENSES & CERTIFICATIONSExtendedTmaxCmax comparedto baseline 0hrs85xC24 compared to baseline 0hrs20xJournal of Pharmacology andPharmacotherapeutics, Sage JournalsXScan to visit websitefor more informationTime (hrs.)020040060080010001200Avg. concentration of Vit. C (ng/ml)0 2 4 6 8 10 12 14 16 18 20 22 24Placebo85x20x

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